About GLP-3
GLP-3 Injections Explained
Weight loss involves more than diet and exercise. Many patients struggle with appetite, cravings, insulin resistance, slow metabolism, hormonal changes, stress, poor sleep, and medical conditions that make weight loss more difficult. That is why the science of weight loss medicine continues to advance.
GLP-3 is a newer term often used to describe investigational triple-action medications that simultaneously target multiple metabolic pathways. At Soboba Medical Weight Loss, our physicians stay current with the latest developments in weight loss medicine — and help patients access the best options available today.
Important: GLP-3 Is Not Yet FDA Approved
GLP-3 medications such as retatrutide are still investigational and have not been approved by the FDA for weight loss or any other condition. Patients should never buy products online claiming to be GLP-3, retatrutide, or research peptides. The FDA has warned that unapproved products may be falsely labeled, illegally marketed, or unsafe.
What Is GLP-3?
GLP-3 is commonly used as an informal term for next-generation triple-action weight loss medications. It is most often used to describe retatrutide — a medication still in clinical trials that has not yet been approved by any regulatory agency for routine patient use.
Unlike traditional GLP-1 medications that target a single receptor, or dual-action medications like tirzepatide that target both GIP and GLP-1 pathways, triple-action medications go one step further by targeting GIP, GLP-1, and glucagon receptors simultaneously — a more aggressive approach to metabolic regulation that researchers are actively studying.
GLP-3 vs. GLP-1 and Dual-Action Medications
GLP-1 (e.g., Ozempic, Wegovy)
Targets the GLP-1 receptor to regulate appetite, digestion, and blood sugar. FDA approved. Available now.
Dual-action (e.g., Mounjaro, Zepbound)
Targets both GIP and GLP-1 pathways for stronger appetite and blood sugar control. FDA approved. Available now.
Triple-action / GLP-3 (e.g., retatrutide)
Targets GIP, GLP-1, and glucagon receptors. Currently investigational. Not FDA approved. Not available for routine patient use.
What Is Available At Soboba Today
While GLP-3 medications are not yet available, Soboba Medical Weight Loss offers several FDA-approved weight loss treatments supervised by licensed physicians. These include proven options such as semaglutide (Ozempic, Wegovy), tirzepatide (Mounjaro), HCG, B-12, B-Complex, and Lipo-B injections.
Patients who are interested in the latest weight loss options should not wait for investigational medications when effective, physician-supervised programs are available now. Your Soboba physician will help you identify the best approach for your health history and goals.
Who May Be A Candidate For Medical Weight Loss?
You may be a candidate for a physician-supervised weight loss program at Soboba if you have struggled to lose weight despite diet and exercise, have regained weight after previous attempts, have a high BMI, or have weight-related health concerns such as high blood pressure, type 2 diabetes, or high cholesterol.
All Soboba Programs Include
Frequently Asked Questions
What Are GLP-3 Injections?
GLP-3 injections is an informal term commonly used to describe next-generation, triple-action weight loss medications being studied for their ability to target multiple metabolic hormone pathways simultaneously.
How Are GLP-3 Injections Different From GLP-1 Injections?
GLP-1 injections primarily target the GLP-1 receptor to regulate appetite, digestion, and blood sugar. Dual-action medications like tirzepatide target both GIP and GLP-1 pathways. Triple-action medications go one step further by targeting GIP, GLP-1, and glucagon receptors.
Are GLP-3 Injections FDA Approved For Weight Loss?
No. At this time, retatrutide — the medication most often associated with the term GLP-3 — is still investigational and has not been approved by the FDA for weight loss or any other condition.
How Do GLP-3 Injections Help With Weight Loss?
Triple-agonist medications are being studied for their ability to reduce appetite, increase fullness, support blood sugar control, and influence how the body processes energy. Clinical data is promising, but these medications are not yet available for routine patient use.
Are GLP-3 Injections Safe?
Because GLP-3-style medications such as retatrutide are still being studied, their full safety profile has not been finalized. Patients should never purchase products online claiming to be GLP-3, retatrutide, or research peptides, as the FDA has warned that unapproved products may be mislabeled, illegally marketed, or unsafe.
Who May Be A Candidate For GLP-3 Injections In The Future?
If approved, candidates may include adults with obesity or adults who are overweight with weight-related health concerns. Candidacy requirements will depend on the final approved labeling. Speak with a Soboba physician about currently available options.
What Are The Possible Side Effects Of GLP-3 Injections?
Possible side effects may be similar to other incretin-based weight loss medications and can include nausea, vomiting, diarrhea, constipation, reduced appetite, stomach discomfort, and dehydration risk. The full side effect profile for retatrutide has not been finalized.
How Often Are GLP-3 Injections Taken?
Retatrutide is being studied as a once-weekly subcutaneous injection in clinical trials. Dosing for any eventual approved product may differ from trial protocols.
Can GLP-3 Injections Be Compounded?
No. The FDA has stated that retatrutide cannot be used in compounding under federal law and has not been found safe and effective for any condition. Patients should avoid any source offering compounded retatrutide.
Should I Wait For GLP-3 Or Start With Available Options Now?
Patients should not wait for investigational medications when effective, FDA-approved options are already available. Soboba physicians can help you start a medically supervised program today using currently approved treatments including semaglutide and tirzepatide.
Start With What Works Now
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FDA-Approved Options Available Now
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Individual results may vary. This content is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. All programs are supervised by licensed physicians. These statements have not been evaluated by the Food and Drug Administration. GLP-3 medications such as retatrutide are investigational and not FDA approved for weight loss or any other condition.